treatment

Intellectual Disability

A. WHAT IS INTELLECTUAL DISABILITY?

The World Health Organization has defined Intellectual Disability (earlier referred to as “Mental Retardation”) as “a condition of arrested or incomplete development of the mind. It is especially characterized by impairment of skills which contribute to the overall level of intelligence.” In simpler terms, intellectual disability is a neurodevelopmental disorder, which affects a child’s learning, reasoning, planning, abstract thinking, problem solving, judgement, academic learning, experiential learning, etc.

Around 1% of the global population is intellectually disabled. Intellectual functioning and adaptive skills are the factors measured to diagnose Intellectual Disability. The average IQ is 100. An IQ less than 70 – 75 is considered as intellectually disabled. Daily living tasks such as communication skills and being able to take care of one’s own needs, are referred to as adaptive skills. Deficits in both, intellectual quotient and adaptive skills, manifest in intellectual disability.

TYPES OF INTELLECTUAL DISABILITIES

Mild Intellectual Disability

  • 85% of individuals with ID are diagnosed with mild intellectual disability
  • The IQ range of these individuals ranges between 50 -69
  • Mild ID individuals take longer to learn to talk, but can communicate well once they learn how to
  • They can be trained to be fully independent in their hygiene and self care
  • Have difficulties in reading and writing
  • Can come across as socially immature
  • May be unable to deal with responsibilities of marriage or parenting
  • Can benefit from specialized educational plans

Moderate Intellectual Disability

  • Individuals with an IQ range of 35 to 49 have Moderate ID
  • Face delays in learning adaptive behaviors
  • May or may not be accompanied with physical abnormalities
  • Face a difficulty in learning to talk
  • May come across as slow in understanding and using language
  • Often have limited communication skills
  • May lag in basic reading, writing and counting skills
  • May find it difficult to live independently, however, they can get around on their own if trained
  • May also be able to take part in simple social activities

Severe Intellectual Disability

  • Severe ID could occur due to a combination of medical or environmental conditions
  • Generally have an IQ range of 20 to 34
  • May have a noticeable motor impairment
  • May be accompanied with behavioral problems and trouble learning
  • Ability to look after themselves is greatly impacted
  • May even exhibit signs of severe damage or abnormal development of the central nervous system
  • May face problems with simple chores such as dressing themselves or feeding themselves
  • May present with a gaping deficit in language and communication
  • Symptoms may become obvious with age

Profound Intellectual Disability

  • Individuals with an IQ range below 20
  • Exhibit severe adaptive and learning delays
  • May even have congenital physical abnormalities
  • May exhibit social development delays
  • Lack of understanding or complying of commands
  • Could even be immobile
  • May use extremely basic nonverbal communication
  • Does not care for their own needs
  • Requires constant help and supervision

SIGNS & SYMPTOMS OF INTELLECTUAL DISABILITY

  • Lack of sense in self-care
  • Below average performance in academics and work
  • Problems in communication and reduced language ability
  • Poor sense of community use
  • Difficulty in self-direction, health and safety
  • Inability to control emotion and behavior
  • Lack of attention and concentration
  • Trouble with memory
  • Poor gross and fine motor coordination
  • Learning, logical thinking and problem-solving difficulties and poor comprehension and response

Depending on the severity of the Intellectual Disability, the individual can be taught new skills and concepts through a modified and supportive educational system, to enable them a life of relative independence, as adults.

CAUSES OF INTELLECTUAL DISABILITY

Intellectual disability can be caused by any condition that hampers normal brain development before or after birth, or during the early childhood years. 

The risk factors or causes of intellectual disability are:

  • Infections that occur at or after birth
  • Genetic anomalies like Down syndrome, Fragile X syndrome, and PKU (phenylketonuria)
  • Metabolic disorders like hyperbilirubinemia and very high bilirubin levels in babies
  • Toxicity by intrauterine exposure to alcohol, cocaine, amphetamines, or other drugs during pregnancy
  • Nutritional deficiencies during pregnancy
  • Trauma to the brain before or during birth; oxygen loss or early childhood sickness, such as whooping cough, measles, or meningitis
  • Environmental factors like lead or mercury poisoning
  • Unknown causes

B. STEM CELL THERAPY FOR INTELLECTUAL DISABILITY 

Stem Cell Treatment for Intellectual Disability, involves autologous bone marrow derived mononuclear cells (BM MNCs) for transplantation. The transplanted stem cells have the ability to migrate to the area of the damaged tissue in the brain and help repair the damage in those affected areas. The effects of damage in those areas are reduced by the release of several trophic factors. These stem cells then also differentiate into several cell types of the nervous system such as oligodendrocytes, glial cells and other cells of the nervous system.

The main mechanisms that help tissue repair and regeneration include:

  • Prevention of cell death in neuronal population
  • Establishment of new blood vessels
  • Cell multiplication and integration
  • Establishment of new neuronal maps in the brain in order to learn new functions

This repair and regeneration of the stem cells in the damaged tissue, restores activity in the affected area, which translates into clinical improvements. Stem cell treatment for Intellectual Disability in India, can thus, prove to play a great role in improving the overall quality of life. Autologous BM MNCs also, do not show any adverse side effects and do not face any immune rejection. They are obtained from the same patient and thus are free of the ethical issues surrounding the use of stem cells.

THE NEUROGEN OUTCOME

In a research trial for Cell treatment for Intellectual Disability in India, at NeuroGen, improvements in areas of cognition, social interaction, communication, toilet training, self care, home living and so on were seen. Age appropriate mental ability, schooling and learning improved to some extent.

Objective radiological evidence in PET-CT Scan of improvement after cell treatment for Intellectual Disability in India

TREATMENTS THAT FOLLOW

The session of stem cell treatment for Traumatic Brain Injury in India together with neurorehabilitation facilitates in restoring the neural network by restoring the cells that are lost and all other cells present in the tissues of the brain. The patients who have experienced an acute Head Injury / Traumatic Brain Injury can restore their old life back through these two successful programs.
  • Physiotherapy
  • Occupational Therapy
  • Dietary Modifications
  • Art Based Therapies
  • Aquatic Therapy
  • Sensory Therapy
  • Speech Therapy
  • Special Education
  • Group Therapies / Motivational Workshops
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